Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC7192606 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Wang Xiaoyan X Zhang Xinyue X Dang Yujie Y Li Duan D Lu Gang G Chan Wai-Yee WY Leung Peter C K PCK Zhao Shidou S Qin Yingying Y Chen Zi-Jiang ZJ
Nucleic acids research 20200501 8
The genetic etiology of premature ovarian insufficiency (POI) has been well established to date, however, the role of long noncoding RNAs (lncRNAs) in POI is largely unknown. In this study, we identified a down-expressed lncRNA HCP5 in granulosa cells (GCs) from biochemical POI (bPOI) patients, which impaired DNA damage repair and promoted apoptosis of GCs. Mechanistically, we discovered that HCP5 stabilized the interaction between YB1 and its partner ILF2, which could mediate YB1 transferring i ...[more]