Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC7192838 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Wang Lu L Liu Zhilan Z Wang Lili L Wu Qielan Q Li Xiang X Xie Di D Zhang Huimin H Zhang Yongdeng Y Gu Lusheng L Xue Yanhong Y Yue Ting T Liu Gang G Ji Wei W Wei Haiming H Xu Tao T Bai Li L
Cellular & molecular immunology 20190603 5
The spatiotemporal distribution of cytokines orchestrates immune responses in vivo, yet the underlying mechanisms remain to be explored. We showed here that the spatial distribution of interleukin-4 (IL4) in invariant natural killer T (iNKT) cells regulated crosstalk between iNKT cells and dendritic cells (DCs) and controlled iNKT cell-mediated T-helper type 1 (Th1) responses. The persistent polarization of IL4 induced by strong lipid antigens, that is, α-galactosylceramide (αGC), caused IL4 acc ...[more]