Iron overload inhibits self-renewal of human pluripotent stem cells via DNA damage and generation of reactive oxygen species.
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ABSTRACT:
SUBMITTER: Han Z
PROVIDER: S-EPMC7193162 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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Iron overload inhibits self-renewal of human pluripotent stem cells via DNA damage and generation of reactive oxygen species.
Han Zhenbo Z Xu Zihang Z Chen Lei L Ye Danyu D Yu Yang Y Zhang Ying Y Cao Yang Y Djibril Bamba B Guo Xiaofei X Gao Xinlu X Zhang Wenwen W Yu Meixi M Liu Shenzhen S Yan Gege G Jin Mengyu M Huang Qi Q Wang Xiuxiu X Hua Bingjie B Feng Chao C Yang Fan F Ma Wenya W Liu Yu Y
FEBS open bio 20200407 5
Iron overload affects the cell cycle of various cell types, but the effect of iron overload on human pluripotent stem cells has not yet been reported. Here, we show that the proliferation capacities of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) were significantly inhibited by ferric ammonium citrate (FAC) in a concentration-dependent manner. In addition, deferoxamine protected hESCs/hiPSCs against FAC-induced cell-cycle arrest. However, iron overload did ...[more]
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