Effects of electronic cigarette liquid solvents propylene glycol and vegetable glycerin on user nicotine delivery, heart rate, subjective effects, and puff topography.

ABSTRACT: BACKGROUND:Electronic cigarettes (ECIGs) are a class of tobacco products that produce different effects (e.g., nicotine delivery), depending on the device, liquid, and behavioral factors. However, the influence of the two primary ECIG liquid solvents, propylene glycol (PG) and vegetable glycerin (VG), on ECIG acute effects is unknown. METHODS:Thirty ECIG-experienced, ?12-h nicotine- abstinent participants completed four conditions consisting of two ECIG-use bouts (10 puffs, 30?s interpuff-interval) differing only by liquid PG:VG ratio (2PG:98VG, 20PG:80VG, 55PG:45VG, 100PG). Device power (7.3?W) and liquid nicotine concentration (18?mg/ml) remained constant. Nicotine delivery, subjective effects, heart rate (HR), and puff topography were assessed. RESULTS:In the 100PG condition, participants took shorter and smaller puffs but obtained significantly more nicotine relative to the two VG-based conditions. Total nicotine exposure (i.e., area under the curve) was also significantly higher during use of the two PG-based liquids. However, participants reported that the 100?PG liquid was significantly less "pleasant" and "satisfying" relative to the other liquids (all ps?

SUBMITTER: Spindle TR 

PROVIDER: S-EPMC7193252 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature