Recent advances in understanding and managing hepatic encephalopathy in chronic liver disease.
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ABSTRACT:
SUBMITTER: Kerbert AJC
PROVIDER: S-EPMC7194462 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Recent advances in understanding and managing hepatic encephalopathy in chronic liver disease.
Kerbert Annarein J C AJC Jalan Rajiv R
F1000Research 20200429
Hepatic encephalopathy (HE) is a common, severe complication of advanced chronic liver disease (CLD) and has a devastating impact on the patient's quality of life and prognosis. The neurotoxin ammonia and the presence of systemic and neurological inflammation are considered the key drivers of this neuropsychiatric syndrome. Treatment options available in routine clinical practice are limited, and the development of novel therapies is hampered owing to the complexity and heterogeneity of HE. This ...[more]
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