Ontology highlight
ABSTRACT:
SUBMITTER: Lee JR
PROVIDER: S-EPMC7195131 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Lee Ju-Ro JR Park Bong-Woo BW Kim Jonghoon J Choo Yeon Woong YW Kim Han Young HY Yoon Jeong-Kee JK Kim Hyeok H Hwang Ji-Won JW Kang Mikyung M Kwon Sung Pil SP Song Seuk Young SY Ko In Ok IO Park Ji-Ae JA Ban Kiwon K Hyeon Taeghwan T Park Hun-Jun HJ Kim Byung-Soo BS
Science advances 20200501 18
Because of poor engraftment and safety concerns regarding mesenchymal stem cell (MSC) therapy, MSC-derived exosomes have emerged as an alternative cell-free therapy for myocardial infarction (MI). However, the diffusion of exosomes out of the infarcted heart following injection and the low productivity limit the potential of clinical applications. Here, we developed exosome-mimetic extracellular nanovesicles (NVs) derived from iron oxide nanoparticles (IONPs)-incorporated MSCs (IONP-MSCs). The r ...[more]