Critical slowing down as a biomarker for seizure susceptibility.
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ABSTRACT:
SUBMITTER: Maturana MI
PROVIDER: S-EPMC7195436 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Critical slowing down as a biomarker for seizure susceptibility.
Maturana Matias I MI Meisel Christian C Dell Katrina K Karoly Philippa J PJ D'Souza Wendyl W Grayden David B DB Burkitt Anthony N AN Jiruska Premysl P Kudlacek Jan J Hlinka Jaroslav J Cook Mark J MJ Kuhlmann Levin L Freestone Dean R DR
Nature communications 20200501 1
The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit critical slowing down, a warning signal preceding many critical transitions in dynamical systems. Using long-term intracranial electroencephalography (iEEG) recordings from fourteen pati ...[more]
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