Ontology highlight
ABSTRACT:
SUBMITTER: Yosifov DY
PROVIDER: S-EPMC7195470 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Yosifov Deyan Yordanov DY Bloehdorn Johannes J Döhner Hartmut H Lichter Peter P Stilgenbauer Stephan S Mertens Daniel D
Scientific data 20200501 1
Acquired resistance to chemotherapy is an important clinical problem and can also occur without detectable cytogenetic aberrations or gene mutations. Chronic lymphocytic leukemia (CLL) is molecularly well characterized and has been elemental for establishing central paradigms in oncology. This prompted us to check whether specific epigenetic changes at the level of DNA methylation might underlie development of treatment resistance. We used Illumina Infinium HumanMethylation450 BeadChips to obtai ...[more]