Ontology highlight
ABSTRACT:
SUBMITTER: Oakes CC
PROVIDER: S-EPMC4134522 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Oakes Christopher C CC Claus Rainer R Gu Lei L Assenov Yassen Y Hüllein Jennifer J Zucknick Manuela M Bieg Matthias M Brocks David D Bogatyrova Olga O Schmidt Christopher R CR Rassenti Laura L Kipps Thomas J TJ Mertens Daniel D Lichter Peter P Döhner Hartmut H Stilgenbauer Stephan S Byrd John C JC Zenz Thorsten T Plass Christoph C
Cancer discovery 20131219 3
Although clonal selection by genetic driver aberrations in cancer is well documented, the ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k arrays and next-generation sequencing to evaluate intratumor heterogeneity and evolution of DNA methylation and genetic aberrations in chronic lymphocytic leukemia (CLL). CLL cases exhibit vast interpatient differences in intratumor methylation heterogeneity, with genetically clonal cases maintaining low methylation hete ...[more]