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Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis.

ABSTRACT: Background:Patients undergoing hemodialysis experience a greater risk of cognitive impairment than the general population, but limited data elucidates the biomarkers on this. We evaluated the association of bone turnover markers on cognitive function among 251 prevalent hemodialysis enrollees in a cross-sectional study. Methods:251 hemodialysis patients (median?age = 57.8, 55% men) and 37 control subjects (mean?age = 61.2, 56% men) without a prior stroke or dementia diagnosis were enrolled. Serum concentrations of 8 bone markers were analyzed as the association of cognitive function (Montreal Cognitive Assessment (MoCA) and Cognitive Abilities Screening Instrument (CASI)) using linear regression analysis. Results:A lower cognitive function was noted in hemodialysis patients compared to control subjects. The receptor activator of nuclear factor kappa-B ligand (RANKL) was the only bone marker found to be associated with cognitive function (MoCA and CASI tests) in hemodialysis patients without a prior stroke or dementia diagnosis. In stepwise multiple linear regression analysis, the association remained significant in MoCA (? = 1.14, 95% CI 0.17 to 2.11) and CASI (? = 3.06, 95% CI 0.24 to 5.88). Short-term memory (? = 0.52, 95% CI 0.01 to 1.02), mental manipulation (? = 0.51, 95% CI 0.05 to 0.96), and abstract thinking (? = 0.57, 95% CI 0.06 to 1.09) were the significant subdomains in the CASI score related to RANKL. Conclusions:Serum RANKL levels were potentially associated with better cognitive function in hemodialysis patients. Further large-scale and prospective studies are needed to confirm our findings.

SUBMITTER: Wu PH

PROVIDER: S-EPMC7196142 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis.

Wu Ping-Hsun PH Lin Yi-Ting YT Chen Cheng-Sheng CS Chiu Yi-Wen YW Tsai Jer-Chia JC Kuo Po-Lin PL Hsu Ya-Ling YL Ljunggren Östen Ö Fellström Bengt B Kuo Mei-Chuan MC

Disease markers 20200421

<h4>Background</h4>Patients undergoing hemodialysis experience a greater risk of cognitive impairment than the general population, but limited data elucidates the biomarkers on this. We evaluated the association of bone turnover markers on cognitive function among 251 prevalent hemodialysis enrollees in a cross-sectional study.<h4>Methods</h4>251 hemodialysis patients (median age = 57.8, 55% men) and 37 control subjects (mean age = 61.2, 56% men) without a prior stroke or dementia diagnosis were ...[more]

PMID: 32377274

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Project description:IntroductionOsteoporosis (OP) is a common polygenic disorder in the aging population, and several single nucleotide polymorphisms (SNPs) in the alpha-L-iduronidase (IDUA) gene and patched homolog 1 (PTCH1) gene regulate bone metabolism and affect bone mass. The study aimed at investigating the relationships of rs3755955 and rs6831280 in the IDUA gene and rs28377268 in the PTCH1 gene with bone mineral density (BMD), bone turnover markers (BTMs), and fractures in the elderly Chinese subjects with OP.Materials and methodsA cohort of 328 unrelated senile osteoporosis (SOP) patients with or without osteoporotic fractures was recruited. rs3755955, rs6831280, and rs28377268 polymorphisms were identified using SNaPshot technology. BTM levels were determined by electrochemiluminescence (ECL). Bone mineral densities (BMDs) at the lumbar spine (LS) and proximal femur sites were measured by dual-energy X-ray absorptiometry (DEXA) in all subjects. The Hardy-Weinberg equilibrium (HWE) test was performed. HWE P values and comparisons of genotype frequencies were estimated using the chi-square test. Analysis of covariance (ANCOVA) adjusted for confounding factors was performed to investigate associations of SNPs with BMDs and BTMs in subgroups.ResultsThe chi-square test indicated that genotype distributions in the control group conformed to HWE (P > 0.05). The distributions of allele and genotype frequencies of rs6831280 between fracture and osteoporotic participants were significantly different (P-allele = 0.002 and P-genotype = 0.012, respectively). Concerning rs6831280, ANCOVA found BMDs at LS 2-4 (L2-4) and total hip (TH) among the study subjects suffering from SOP with GA genotype were lower than in those carrying GG or AA (P-L2-4 = 0.004 and P-TH = 0.027, respectively).ConclusionsIDUA rs6831280 is associated with BMDs at L2-4 and TH in the elderly Chinese population with SOP and may serve as a marker for the genetic susceptibility to osteoporotic fractures.

Dataset Information

Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis.

Publications

Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis.

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