Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis.

ABSTRACT:

Background

Patients undergoing hemodialysis experience a greater risk of cognitive impairment than the general population, but limited data elucidates the biomarkers on this. We evaluated the association of bone turnover markers on cognitive function among 251 prevalent hemodialysis enrollees in a cross-sectional study.

Methods

251 hemodialysis patients (median age = 57.8, 55% men) and 37 control subjects (mean age = 61.2, 56% men) without a prior stroke or dementia diagnosis were enrolled. Serum concentrations of 8 bone markers were analyzed as the association of cognitive function (Montreal Cognitive Assessment (MoCA) and Cognitive Abilities Screening Instrument (CASI)) using linear regression analysis.

Results

A lower cognitive function was noted in hemodialysis pa

SUBMITTER: Wu PH 

PROVIDER: S-EPMC7196142 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature