Heritable modifiers of the tumor microenvironment influence nanoparticle uptake, distribution and response to photothermal therapy.

ABSTRACT: We report the impact of notch-DLL4-based hereditary vascular heterogeneities on the enhanced permeation and retention (EPR) effect and plasmonic photothermal therapy response in tumors. Methods: We generated two consomic rat strains with differing DLL4 expression on 3^rd chromosome. These strains were based on immunocompromised Salt-sensitive or SS^IL2Rγ- (DLL4-high) and SS.BN3^IL2Rγ- (DLL4-low) rats with 3rd chromosome substituted from Brown Norway rat. We further constructed three novel SS.BN3^IL2Rγ- congenic strains by introgressing varying segments of BN chromosome 3 into the parental SS^IL2Rγ- strain to localize the role of SS^IL2Rγ- DLL4 on tumor EPR effect with precision. We synthesized multimodal theranostic nanopar

SUBMITTER: Sharma G 

PROVIDER: S-EPMC7196309 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature