Genetic Modifiers of the Breast Tumor Microenvironment.
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ABSTRACT:
SUBMITTER: Flister MJ
PROVIDER: S-EPMC5990047 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Genetic Modifiers of the Breast Tumor Microenvironment.
Flister Michael J MJ Bergom Carmen C
Trends in cancer 20180508 6
Multiple nonmalignant cell types in the tumor microenvironment (TME) impact breast cancer risk, metastasis, and response to therapy, yet most heritable mechanisms that influence TME cell function and breast cancer outcomes are largely unknown. Breast cancer risk is ∼30% heritable and >170 genetic loci have been associated with breast cancer traits. However, the majority of candidate genes have poorly defined mechanistic roles in breast cancer biology. Research indicates that breast cancer risk m ...[more]
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