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Quantitative three-dimensional ultrashort echo time cones imaging of the knee joint with motion correction.

ABSTRACT: Knee degeneration involves all the major tissues in the joint. However, conventional MRI sequences can only detect signals from long T2 tissues such as the superficial cartilage, with little signal from the deep cartilage, menisci, ligaments, tendons and bone. It is highly desirable to develop new sequences that can detect signal from all major tissues in the knee. We aimed to develop a comprehensive quantitative three-dimensional ultrashort echo time (3D UTE) cones imaging protocol for a truly "whole joint" evaluation of knee degeneration. The protocol included 3D UTE cones actual flip angle imaging (3D UTE-Cones-AFI) for T₁ mapping, multiecho UTE-Cones with fat suppression for T₂ * mapping, UTE-Cones with adiabatic T_1? (AdiabT_1? ) preparation for AdiabT_1? mapping, and UTE-Cones magnetization transfer (UTE-Cones-MT) for MT ratio (MTR) and modeling of macromolecular proton fraction (f). An elastix registration technique was used to compensate for motion during scans. Quantitative data analyses were performed on the registered data. Three knee specimens and 15 volunteers were evaluated at 3 T. The elastix motion correction algorithm worked well in correcting motion artifacts associated with relatively long scan times. Much improved curve fitting was achieved for all UTE-Cones biomarkers with greatly reduced root mean square errors. The averaged T₁ , T₂ *, AdiabT_1? , MTR and f for knee joint tissues of 15 healthy volunteers were reported. The 3D UTE-Cones quantitative imaging techniques (ie, T₁ , T₂ *, AdiabT_1? , MTR and MT modeling) together with elastix motion correction provide robust volumetric measurement of relaxation times, MTR and f of both short and long T₂ tissues in the knee joint.

SUBMITTER: Wu M

PROVIDER: S-EPMC7197345 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Quantitative three-dimensional ultrashort echo time cones imaging of the knee joint with motion correction.

Wu Mei M Zhao Wei W Wan Lidi L Kakos Lena L Li Liang L Jerban Saeed S Jang Hyungseok H Chang Eric Y EY Du Jiang J Ma Ya-Jun YJ

NMR in biomedicine 20191112 1

Knee degeneration involves all the major tissues in the joint. However, conventional MRI sequences can only detect signals from long T2 tissues such as the superficial cartilage, with little signal from the deep cartilage, menisci, ligaments, tendons and bone. It is highly desirable to develop new sequences that can detect signal from all major tissues in the knee. We aimed to develop a comprehensive quantitative three-dimensional ultrashort echo time (3D UTE) cones imaging protocol for a truly ...[more]

PMID: 31713936

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Project description:BackgroundRecent studies suggest that macromolecular fraction (MMF) derived from three-dimensional ultrashort echo time magnetization transfer (UTE-MT) imaging is insensitive to the magic angle effect. However, its clinical use in osteoarthritis (OA) remains to be investigated.PurposeTo investigate the feasibility of 3D UTE-MT-derived MMF in differentiating normal from degenerated cartilage.Study typeProspective.SubjectsSixty-two participants (54.8 ± 16.7 years, 30 females) with and without OA, plus two healthy volunteers (mean age 35.0 years) for reproducibility test.Field strength/sequence3 T/UTE-MT sequence.AssessmentA 3D UTE-MT sequence was employed to calculate MMF based on a two-pool model. Kellgren-Lawrence (KL) grade and Whole-Organ Magnetic Resonance Imaging Score (WORMS) were evaluated by three experienced musculoskeletal radiologists. KL grade was condensed into three groups: KL0, KL1-2, and KL3-4. WORMS was regrouped based on extent of lesion (extent group) and depth of lesion (depth group), respectively. The performance of MMF at evaluating the degeneration of cartilage was assessed via Spearman's correlation coefficient and the area under the curve (AUC) calculated according to the receiver-operating characteristic curve.Statistical testsAfter normality check, one-way analysis of variance was used to evaluate the performance. Tukey-Kramer test was performed for post hoc testing.ResultsMMF showed significant negative correlations with KL grade (r = -0.53, P < 0.05) and WORMS (r = -0.49, P < 0.05). Significantly lower MMFs were found in subjects with greater KL grade (11.8 ± 0.8% for KL0; 10.9 ± 0.9% for KL1-2; 10.6 ± 1.1% for KL3-4; P < 0.05) and in cartilage with greater extent (12.1 ± 1.6% for normal cartilage; 10.9 ± 1.6% for regional lesions; 9.6 ± 1.7% for diffuse lesions; P < 0.05) and depth (12.1 ± 1.6% for normal cartilage; 10.6 ± 1.6% for partial-thickness lesions; 8.8 ± 1.7% for full-thickness lesions; P < 0.05) of lesions. AUC values of MMF for doubtful-minimal OA (KL1-2) and mild cartilage degradation (WORMS1-2) were 0.8 and 0.7, respectively.Data conclusionThis study highlights the clinical potential of MMF in the detection of early OA.Level of evidence2 TECHNICAL EFFICACY STAGE: 2.

Dataset Information

Quantitative three-dimensional ultrashort echo time cones imaging of the knee joint with motion correction.

Publications

Quantitative three-dimensional ultrashort echo time cones imaging of the knee joint with motion correction.

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