Insomnia and Neurocognitive Functioning in Adult Survivors of Childhood Cancer.

ABSTRACT: Background:In noncancer populations, insomnia is known to affect neurocognitive processes. Although the prevalence of insomnia appears to be elevated in survivors of childhood cancer, relatively little is known about its association with neurocognitive performance in this at-risk population. Methods:A total of 911 survivors (51.9% female; mean [SD] age, 34 [9.0] years; time since diagnosis, 26 [9.1] years) completed direct assessments of attention, memory, processing speed, and executive functioning and self-reported symptoms of sleep (Pittsburgh Sleep Quality Index), fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue), and daytime sleepiness (Epworth Sleepiness Scale). Sex-stratified general linear models were used to examine associations between insomnia and neurocognitive performance, with adjustment for treatment exposures and chronic health conditions. All statistical tests were two-sided. Results:Insomnia was reported by 22.1% of females and 12.3% of males (P?

SUBMITTER: Tonning Olsson I 

PROVIDER: S-EPMC7197383 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature