Ontology highlight
ABSTRACT:
SUBMITTER: Mudumbi KC
PROVIDER: S-EPMC7198523 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Mudumbi Krishna C KC Czapiewski Rafal R Ruba Andrew A Junod Samuel L SL Li Yichen Y Luo Wangxi W Ngo Christina C Ospina Valentina V Schirmer Eric C EC Yang Weidong W
Nature communications 20200504 1
Roughly 10% of eukaryotic transmembrane proteins are found on the nuclear membrane, yet how such proteins target and translocate to the nucleus remains in dispute. Most models propose transport through the nuclear pore complexes, but a central outstanding question is whether transit occurs through their central or peripheral channels. Using live-cell high-speed super-resolution single-molecule microscopy we could distinguish protein translocation through the central and peripheral channels, find ...[more]