Ontology highlight
ABSTRACT:
SUBMITTER: Au FKC
PROVIDER: S-EPMC7199859 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
The Journal of cell biology 20200501 5
Centrosome disjunction occurs in late G2 to facilitate bipolar spindle formation and is mediated by the NIMA-related kinase Nek2. Here, we show that GAS2L1, a microtubule- and F-actin-binding protein required for centrosome disjunction, undergoes Nek2-mediated phosphorylation at Ser352 in G2/M. The phosphorylation is essential for centrosome disjunction in late G2 and for proper spindle assembly and faithful chromosome segregation in mitosis. GAS2L1 contains a calponin-homology (CH) domain and a ...[more]