Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee S
PROVIDER: S-EPMC7202956 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Banerjee Sudeep S Yoon Hyunho H Yebra Mayra M Tang Chih-Min CM Gilardi Mara M Shankara Narayanan Jayanth S JS White Rebekah R RR Sicklick Jason K JK Ray Partha P
Molecular cancer therapeutics 20200303 5
Gastrointestinal stromal tumor (GIST), the most common sarcoma, is characterized by KIT protein overexpression, and tumors are frequently driven by oncogenic <i>KIT</i> mutations. Targeted inhibition of KIT revolutionized GIST therapy and ushered in the era of precision medicine for the treatment of solid malignancies. Here, we present the first use of a KIT-specific DNA aptamer for targeted labeling of GIST. We found that an anti-KIT DNA aptamer bound cells in a KIT-dependent manner and was hig ...[more]