Dataset Information

Alterations in Salience Network Functional Connectivity in Individuals with Restless Legs Syndrome.

ABSTRACT: BACKGROUND AND PURPOSE:Restless legs syndrome (RLS) is a neurological disorder which is most commonly identified by an urge to move the legs. It often shows alterations in sensory processing which implies the salience network (SN) is experiencing changes. This study investigates the functional connectivity (FC) between the SN and other areas of the brain in RLS patients during the resting state period. METHODS:Thirty patients with drug naïve idiopathic RLS and 30 healthy age and gender matched controls were included in this study. Resting state fMRIs were performed in the morning during the asymptomatic period. The SN comparisons were conducted between the two groups. RESULTS:The RLS group showed a reduction in SN FC in the right pyramis, and an increase in SN FC in the bilateral orbitofrontal gyri and right postcentral gyrus. CONCLUSIONS:The results of this study give reason to believe that SN FC in RLS patients is altered during asymptomatic periods. This could have an influence on the processing of the saliency of information, particularly sensory information processing and inhibition mechanisms.

SUBMITTER: Ku J

PROVIDER: S-EPMC7203171 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Alterations in Salience Network Functional Connectivity in Individuals with Restless Legs Syndrome.

Ku Jeonghun J Lee Yeong Seon YS Kim Keun Tae KT Chang HyukWon H Cho Yong Won YW

Scientific reports 20200506 1

<h4>Background and purpose</h4>Restless legs syndrome (RLS) is a neurological disorder which is most commonly identified by an urge to move the legs. It often shows alterations in sensory processing which implies the salience network (SN) is experiencing changes. This study investigates the functional connectivity (FC) between the SN and other areas of the brain in RLS patients during the resting state period.<h4>Methods</h4>Thirty patients with drug naïve idiopathic RLS and 30 healthy age and g ...[more]

PMID: 32377013

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Project description:Background and purposeFunctional connectivity studies revealed alterations within thalamic, salience, and default mode networks in restless legs syndrome patients.MethodsEighty-two patients with restless legs syndrome (untreated, n = 30; on dopaminergic medication, n = 42; on alpha-2-delta ligands as mono- or polytherapy combined with dopaminergic medication, n = 10), and 82 individually age- and gender-matched healthy controls were studied with resting-state functional magnetic resonance imaging. Connectivity of 12 resting-state networks was investigated with independent component analysis, and network topology was studied with graph methods among 410 brain regions.ResultsPatients with restless legs syndrome showed significantly higher connectivity within salience (p = 0.029), executive (p = 0.001), and cerebellar (p = 0.041) networks, as well as significantly lower (p < 0.05) cerebello-frontal communication compared to controls. In addition, they had a significantly higher (p < 0.05) clustering coefficient and local efficiency in motor and frontal regions; lower clustering coefficient in the central sulcus; and lower local efficiency in the central opercular cortex, temporal, parieto-occipital, cuneus, and occipital regions compared to controls. Untreated patients had significantly lower (p < 0.05) cerebello-parietal communication compared to healthy controls. Connectivity between the thalamus and frontal regions was significantly increased (p < 0.05) in patients on dopaminergic medication compared to untreated patients and controls.ConclusionsNetworks with higher intranetwork connectivity (i.e., salience, executive, cerebellar) and lower cerebello-frontal connectivity in the restless legs syndrome patients, as well as lower cerebello-parietal connectivity in untreated patients, correspond to regions associated with attention, response inhibitory control, and processing of sensory information. Intact cerebello-parietal communication and increased thalamic connectivity to the prefrontal regions in patients on dopaminergic medication suggests a treatment effect on thalamus.

Dataset Information

Alterations in Salience Network Functional Connectivity in Individuals with Restless Legs Syndrome.

Publications

Alterations in Salience Network Functional Connectivity in Individuals with Restless Legs Syndrome.

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