Ontology highlight
ABSTRACT:
SUBMITTER: Stassen SV
PROVIDER: S-EPMC7203756 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Stassen Shobana V SV Siu Dickson M D DMD Lee Kelvin C M KCM Ho Joshua W K JWK So Hayden K H HKH Tsia Kevin K KK
Bioinformatics (Oxford, England) 20200501 9
<h4>Motivation</h4>New single-cell technologies continue to fuel the explosive growth in the scale of heterogeneous single-cell data. However, existing computational methods are inadequately scalable to large datasets and therefore cannot uncover the complex cellular heterogeneity.<h4>Results</h4>We introduce a highly scalable graph-based clustering algorithm PARC-Phenotyping by Accelerated Refined Community-partitioning-for large-scale, high-dimensional single-cell data (>1 million cells). Usin ...[more]