Ontology highlight
ABSTRACT:
SUBMITTER: Lin P
PROVIDER: S-EPMC5371246 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lin Peijie P Troup Michael M Ho Joshua W K JW
Genome biology 20170328 1
Most existing dimensionality reduction and clustering packages for single-cell RNA-seq (scRNA-seq) data deal with dropouts by heavy modeling and computational machinery. Here, we introduce CIDR (Clustering through Imputation and Dimensionality Reduction), an ultrafast algorithm that uses a novel yet very simple implicit imputation approach to alleviate the impact of dropouts in scRNA-seq data in a principled manner. Using a range of simulated and real data, we show that CIDR improves the standar ...[more]