Ontology highlight
ABSTRACT:
SUBMITTER: Diaz C
PROVIDER: S-EPMC7204593 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Diaz Clemente C Koren Michael M Lin Leyi L Martinez Luis J LJ Eckels Kenneth H KH Campos Maribel M Jarman Richard G RG De La Barrera Rafael R Lepine Edith E Febo Irma I Vaughn David W DW Wilson Todd M TM Paris Robert M RM Schmidt Alexander C AC Thomas Stephen J SJ
The American journal of tropical medicine and hygiene 20200501 5
Four formulations of an investigational tetravalent dengue purified inactivated vaccine, administered as two doses one month (M) apart, were previously shown to be immunogenic and well-tolerated up to M13 of the phase I study NCT01702857. Here, we report results of the follow-up from M14 to year (Y) 3. One hundred healthy Puerto Rican adults, predominantly dengue virus (DENV)-primed, were randomized 1:1:1:1:1 to receive placebo or vaccine formulations: 1 μg/serotype/dose adjuvanted with aluminum ...[more]