Ontology highlight
ABSTRACT:
SUBMITTER: Suo Y
PROVIDER: S-EPMC7205012 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Suo Yang Y Wang Zilong Z Zubcevic Lejla L Hsu Allen L AL He Qianru Q Borgnia Mario J MJ Ji Ru-Rong RR Lee Seok-Yong SY
Neuron 20191219 5
Transient receptor potential channel subfamily A member 1 (TRPA1) is a Ca<sup>2+</sup>-permeable cation channel that serves as one of the primary sensors of environmental irritants and noxious substances. Many TRPA1 agonists are electrophiles that are recognized by TRPA1 via covalent bond modifications of specific cysteine residues located in the cytoplasmic domains. However, a mechanistic understanding of electrophile sensing by TRPA1 has been limited due to a lack of high-resolution structural ...[more]