Ontology highlight
ABSTRACT:
SUBMITTER: Panzer JK
PROVIDER: S-EPMC7205437 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Panzer Julia K JK Hiller Helmut H Cohrs Christian M CM Almaça Joana J Enos Stephen J SJ Beery Maria M Cechin Sirlene S Drotar Denise M DM Weitz John R JR Santini Jorge J Huber Mollie K MK Muhammad Fahd Qadir Mirza M Pastori Ricardo L RL Domínguez-Bendala Juan J Phelps Edward A EA Atkinson Mark A MA Pugliese Alberto A Caicedo Alejandro A Kusmartseva Irina I Speier Stephan S
JCI insight 20200423 8
In type 1 diabetes (T1D), autoimmune destruction of pancreatic β cells leads to insulin deficiency and loss of glycemic control. However, knowledge about human pancreas pathophysiology in T1D remains incomplete. To address this limitation, we established a pancreas tissue slice platform of donor organs with and without diabetes, facilitating the first live cell studies of human pancreas in T1D pathogenesis to our knowledge. We show that pancreas tissue slices from organ donors allow thorough ass ...[more]