Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique for ¹³N-Ammonia Positron Emission Tomography Cardiac Perfusion Studies.

ABSTRACT:

Background

We previously proposed a technique for quantitative measurement of rest and stress absolute myocardial blood flow (MBF) using a 2-injection single-scan imaging session. Recently, we validated the method in a pig model for the long-lived radiotracer ¹⁸F-Flurpiridaz with adenosine as a pharmacological stressor. The aim of the present work is to validate our technique for ¹³NH₃.

Methods

Nine studies were performed in 6 pigs; 5 studies were done in the native state and 4 after infarction of the left anterior descending artery. Each study consisted of 3 dynamic scans: a 2-injection rest-rest single-scan acquisition (scan A), a 2-injection rest/stress single-scan acquisition (scan B), and a conventional 1-injection stress acquisition (sc

SUBMITTER: Guehl NJ 

PROVIDER: S-EPMC7205554 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature