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A fine balance: Immunosuppression and immunotherapy in a patient with multiple sclerosis and COVID-19.


ABSTRACT: BACKGROUND:Treatment decisions in patients with multiple sclerosis (MS) during the coronavirus disease 2019 (COVID-19) pandemic are challenging. It is not known whether and how various disease modifying therapies, especially immunosuppressive drugs, affect COVID-19 risk and disease course. METHODS:Case report RESULTS: We report a fingolimod-treated MS patient who developed severe COVID-19 but recovered after treatment with tocilizumab. CONCLUSION:This report suggests that a brief course of tocilizumab for the treatment of severe COVID-19 may be effective while not aggravating pre-existing MS.

SUBMITTER: Valencia-Sanchez C 

PROVIDER: S-EPMC7205685 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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A fine balance: Immunosuppression and immunotherapy in a patient with multiple sclerosis and COVID-19.

Valencia-Sanchez Cristina C   Wingerchuk Dean M DM  

Multiple sclerosis and related disorders 20200508


<h4>Background</h4>Treatment decisions in patients with multiple sclerosis (MS) during the coronavirus disease 2019 (COVID-19) pandemic are challenging. It is not known whether and how various disease modifying therapies, especially immunosuppressive drugs, affect COVID-19 risk and disease course.<h4>Methods</h4>Case report RESULTS: We report a fingolimod-treated MS patient who developed severe COVID-19 but recovered after treatment with tocilizumab.<h4>Conclusion</h4>This report suggests that a  ...[more]

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