Head and neck tumors angiogenesis imaging with 68Ga-NODAGA-RGD in comparison to 18F-FDG PET/CT: a pilot study.

ABSTRACT: BACKGROUND:Angiogenesis plays an important role in head and neck squamous cell carcinoma (HNSCC) progression. This pilot study was designed to compare the distribution of 68Ga-NODAGA-RGD PET/CT for imaging ?v?3 integrins involved in tumor angiogenesis to 18F-FDG PET/CT in patients with HNSCC. MATERIAL AND METHODS:Ten patients (aged 58.4 ± 8.3?years [range, 44-73?years], 6 males, 4 females) with a total of 11 HNSCC were prospectively enrolled. Activity mapping and standard uptake values (SUV) from both 68Ga-NODAGA-RGD and 18F-FDG PET/CT scans were recorded for primary tumor and compared with the Wilcoxon signed-rank test. The relation between the SUV of both tracers was assessed using the Spearman correlation. RESULTS:All HNSCC tumors were visible with both tracers. Quantitative analysis showed higher 18F-FDG SUVmax in comparison to 68Ga-NODAGA-RGD (14.0 ± 6.1 versus 3.9 ± 1.1?g/mL, p = 0.0017) and SUVmean (8.2 ± 3.1 versus 2.0 ± 0.8?g/mL, p = 0.0017). Both 18F-FDG and 68Ga-NODAGA-RGD uptakes were neither correlated with grade, HPV status nor p16 protein expression (p ? 0.17). CONCLUSION:All HNSCC tumors were detected with both tracers with higher uptake with 18F-FDG, however. 68Ga-NODAGA-RGD has a different spatial distribution than 18F-FDG bringing different tumor information. TRIAL REGISTRATION:NCT, NCT02666547. Registered 12.8.2012.

SUBMITTER: Durante S 

PROVIDER: S-EPMC7205972 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature