Ontology highlight
ABSTRACT:
SUBMITTER: Jacobs SBR
PROVIDER: S-EPMC7205994 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Jacobs Suzanne B R SBR Van Nostrand Jeanine L JL Bowen Margot E ME Baker Julie C JC Attardi Laura D LD
Cell death and differentiation 20190604 1
The Siva protein, named after the Hindu God of Destruction, plays important roles in apoptosis in various contexts, including downstream of death receptor activation or p53 tumor suppressor engagement. The function of Siva in organismal development and homeostasis, however, has remained uncharacterized. Here, we generate Siva knockout mice to characterize the physiological function of Siva in vivo. Interestingly, we find that Siva deficiency causes early embryonic lethality accompanied by multip ...[more]