Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC7206060 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Liu Hao H Song Ying Y Qiu Huishi H Liu Yanzhen Y Luo Kai K Yi Yanmei Y Jiang Guanmin G Lu Minying M Zhang Zhijie Z Yin Jiang J Zeng Shanshan S Chen Xiangzhou X Deng Min M Jia Xiaoting X Gu Yixue Y Chen Danyang D Zheng Guopei G He Zhimin Z
Cell death and differentiation 20190711 3
Breast cancer stem cells (BCSCs) are tumor initiating cells that can self-renew and are highly tumorigenic and chemoresistant. Therefore, the identification of factors critical for BCSC function is vital for the development of therapies. Here, we report that DNMT1-mediated FOXO3a promoter hypermethylation leads to downregulation of FOXO3a expression in breast cancer. FOXO3a is functionally related to the inhibition of FOXM1/SOX2 signaling and to the consequent suppression of BCSCs properties and ...[more]