Ontology highlight
ABSTRACT:
SUBMITTER: Pathania R
PROVIDER: S-EPMC4410389 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nature communications 20150424
Mammary stem/progenitor cells (MaSCs) maintain self-renewal of the mammary epithelium during puberty and pregnancy. DNA methylation provides a potential epigenetic mechanism for maintaining cellular memory during self-renewal. Although DNA methyltransferases (DNMTs) are dispensable for embryonic stem cell maintenance, their role in maintaining MaSCs and cancer stem cells (CSCs) in constantly replenishing mammary epithelium is unclear. Here we show that DNMT1 is indispensable for MaSC maintenance ...[more]