Ontology highlight
ABSTRACT:
SUBMITTER: Park JS
PROVIDER: S-EPMC7210009 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Park Jin Suk JS Burckhardt Christoph J CJ Lazcano Rossana R Solis Luisa M LM Isogai Tadamoto T Li Linqing L Chen Christopher S CS Gao Boning B Minna John D JD Bachoo Robert R DeBerardinis Ralph J RJ Danuser Gaudenz G
Nature 20200212 7796
The mechanics of the cellular microenvironment continuously modulates cell functions such as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal remodelling and actomyosin contractility<sup>1-3</sup>. Although all of these processes consume energy<sup>4,5</sup>, it is unknown whether and how cells adapt their metabolic activity to variable mechanical cues. Here we report that the transfer of human bronchial epithelial cells from stiff to soft substrates causes a downr ...[more]