Ontology highlight
ABSTRACT:
SUBMITTER: Hujoel MLA
PROVIDER: S-EPMC7210076 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature genetics 20200420 5
Family history of disease can provide valuable information in case-control association studies, but it is currently unclear how to best combine case-control status and family history of disease. We developed an association method based on posterior mean genetic liabilities under a liability threshold model, conditional on case-control status and family history (LT-FH). Analyzing 12 diseases from the UK Biobank (average N = 350,000) we compared LT-FH to genome-wide association without using famil ...[more]