Unknown

Dataset Information

0

Functional brain network characteristics are associated with epilepsy severity in childhood absence epilepsy.


ABSTRACT: While cognitive impairments are not generally considered to be part of the childhood absence epilepsy (CAE) syndrome, some recent studies report cognitive, mainly attentional, deficits. Here we set out to investigate the whole brain functional network of children with CAE and controls. Furthermore, the possible relation of the functional network abnormalities with epilepsy and neurocognitive characteristics is studied. Seventeen children with childhood CAE (aged 9.2?±?2.1 years) and 15 controls (aged 9.8?±?1.8 years) were included. Resting state functional MRI was acquired to study the functional network. Using graph theoretical analysis, three global metrics of the functional network were investigated: the characteristic path length, the clustering coefficient, and the small-worldness. A multivariable linear regression model including age, sex, and subject motion as covariates was used to investigate group differences in the graph metrics. Subsequently, relations of the graph metrics with epilepsy and neurocognitive characteristics were assessed. Longer path lengths, weaker clustering and a lower small-world network topology were observed in children with CAE compared to controls. Moreover, longer path lengths were related to a longer duration of CAE and a higher number of absence seizure per hour. Clustering and small-worldness were not significantly related to epilepsy or neurocognitive characteristics. The organization of the functional network of children with CAE is less efficient compared to controls, and is related to disease duration. These preliminary findings suggest that CAE is associated with alterations in the functional network.

SUBMITTER: Drenthen GS 

PROVIDER: S-EPMC7210592 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Functional brain network characteristics are associated with epilepsy severity in childhood absence epilepsy.

Drenthen Gerhard S GS   Fasen Floor F   Fonseca Wald Eric L A ELA   Backes Walter H WH   Aldenkamp Albert P AP   Vermeulen R Jeroen RJ   Debeij-van Hall Mariette M   Hendriksen Jos J   Klinkenberg Sylvia S   Jansen Jacobus F A JFA  

NeuroImage. Clinical 20200423


While cognitive impairments are not generally considered to be part of the childhood absence epilepsy (CAE) syndrome, some recent studies report cognitive, mainly attentional, deficits. Here we set out to investigate the whole brain functional network of children with CAE and controls. Furthermore, the possible relation of the functional network abnormalities with epilepsy and neurocognitive characteristics is studied. Seventeen children with childhood CAE (aged 9.2 ± 2.1 years) and 15 controls  ...[more]

Similar Datasets

| S-EPMC3105167 | biostudies-other
| S-EPMC7541981 | biostudies-literature
| S-EPMC3109878 | biostudies-literature
| S-EPMC10060817 | biostudies-literature
| S-EPMC5607318 | biostudies-literature
| S-EPMC10855957 | biostudies-literature
| S-EPMC5224720 | biostudies-literature
| S-EPMC3942412 | biostudies-literature
| S-EPMC5562968 | biostudies-literature
| S-EPMC10213928 | biostudies-literature