Distinct microbial and immune niches of the human colon.
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ABSTRACT:
SUBMITTER: James KR
PROVIDER: S-EPMC7212050 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Distinct microbial and immune niches of the human colon.
James Kylie R KR Gomes Tomas T Elmentaite Rasa R Kumar Nitin N Gulliver Emily L EL King Hamish W HW Stares Mark D MD Bareham Bethany R BR Ferdinand John R JR Petrova Velislava N VN Polański Krzysztof K Forster Samuel C SC Jarvis Lorna B LB Suchanek Ondrej O Howlett Sarah S James Louisa K LK Jones Joanne L JL Meyer Kerstin B KB Clatworthy Menna R MR Saeb-Parsy Kourosh K Lawley Trevor D TD Teichmann Sarah A SA
Nature immunology 20200217 3
Gastrointestinal microbiota and immune cells interact closely and display regional specificity; however, little is known about how these communities differ with location. Here, we simultaneously assess microbiota and single immune cells across the healthy, adult human colon, with paired characterization of immune cells in the mesenteric lymph nodes, to delineate colonic immune niches at steady state. We describe distinct helper T cell activation and migration profiles along the colon and charact ...[more]
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