The Role of DLLs in Cancer: A Novel Therapeutic Target.
Ontology highlight
ABSTRACT:
SUBMITTER: Xiu MX
PROVIDER: S-EPMC7213894 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
The Role of DLLs in Cancer: A Novel Therapeutic Target.
Xiu Meng-Xi MX Liu Yuan-Meng YM Kuang Bo-Hai BH
OncoTargets and therapy 20200507
Delta-like ligands (DLLs) control Notch signaling. DLL1, DLL3 and DLL4 are frequently deregulated in cancer and influence tumor growth, the tumor vasculature and tumor immunity, which play different roles in cancer progression. DLLs have attracted intense research interest as anti-cancer therapeutics. In this review, we discuss the role of DLLs in cancer and summarize the emerging DLL-relevant targeting methods to aid future studies. ...[more]
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