Ontology highlight
ABSTRACT:
SUBMITTER: van de Veerdonk FL
PROVIDER: S-EPMC7213974 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
eLife 20200427
COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs. SARS-CoV-2 enters the cell via ACE2 that next to its role in RAAS is needed to inactivate des-Arg9 bradykinin, the potent ligand of the B1R. Without ACE2 acting as a guardian to inactivate the ligands of B1R, the lung environment is prone for local vascular leakage leading to an ...[more]