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Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity.

ABSTRACT: The angiotensin converting enzyme-2 (ACE2) cellular receptor is responsible for the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upregulating ACE2, whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2. As such, we postulate on the biological plausibility of interactions between dietary fat and/or resveratrol and ACE2 gene variations in the modulation of SARS-CoV-2 illness severity. We call to action the research community to test this plausible interaction in a sample of human subjects.

SUBMITTER: Horne JR

PROVIDER: S-EPMC7215091 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity.

Horne Justine R JR Vohl Marie-Claude MC

American journal of physiology. Endocrinology and metabolism 20200420 5

The angiotensin converting enzyme-2 (ACE2) cellular receptor is responsible for the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upre ...[more]

PMID: 32310688

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