Ontology highlight
ABSTRACT:
SUBMITTER: Kim CM
PROVIDER: S-EPMC7215387 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kim Chang Min CM Park Hyun Ho HH
International journal of molecular sciences 20200421 8
Although TRAF1 and TRAF2 share common receptors and have extremely conserved amino acid residues, recent studies have shown that key differences in receptor binding preferences with different affinities exist, which might be important for their different functions in TRAF-mediated signal transduction. To better understand TRAF1 and TRAF2 signaling, we analyzed and compared their receptor binding-affinities. Our study revealed that TRADD, TANK, and caspase-2 bind to both TRAF1 and TRAF2 with diff ...[more]