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Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors.

ABSTRACT: In our efforts to find new and selective thiazolidinone-based anti-Candida agents, we synthesized and tested 26 thiazolidinones against several Candida spp. and Gram-positive and Gram-negative bacteria. The compounds showed selective antifungal activity with potency similar to fluconazole and clotrimazole, while lacking strong antibacterial activity. Molecular docking and molecular dynamics studies were performed on Candida CYP51a1 and carbonic anhydrase (CA) enzymes to further suggest putative targets that could mediate the antifungal effects of these compounds. Finally, the compounds were tested in enzyme inhibition assays to assess their putative mechanism of action and showed promising KI values in the 0.1-10 µM range against the Candida glabrata ?-CA enzyme CgNce103.

SUBMITTER: Guzel-Akdemir O

PROVIDER: S-EPMC7215574 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors.

Güzel-Akdemir Özlen Ö Carradori Simone S Grande Rossella R Demir-Yazıcı Kübra K Angeli Andrea A Supuran Claudiu T CT Akdemir Atilla A

International journal of molecular sciences 20200422 8

In our efforts to find new and selective thiazolidinone-based anti-Candida agents, we synthesized and tested 26 thiazolidinones against several Candida spp. and Gram-positive and Gram-negative bacteria. The compounds showed selective antifungal activity with potency similar to fluconazole and clotrimazole, while lacking strong antibacterial activity. Molecular docking and molecular dynamics studies were performed on Candida CYP51a1 and carbonic anhydrase (CA) enzymes to furt ...[more]

PMID: 32331447

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