Ontology highlight
ABSTRACT:
SUBMITTER: Han S
PROVIDER: S-EPMC7215771 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Han Seokgyu S Kim Sein S Chen Zhenzhong Z Shin Hwa Kyoung HK Lee Seo-Yeon SY Moon Hyo Eun HE Paek Sun Ha SH Park Sungsu S
International journal of molecular sciences 20200423 8
An in vitro screening system for anti-cancer drugs cannot exactly reflect the efficacy of drugs in vivo, without mimicking the tumour microenvironment (TME), which comprises cancer cells interacting with blood vessels and fibroblasts. Additionally, the tumour size should be controlled to obtain reliable and quantitative drug responses. Herein, we report a bioprinting method for recapitulating the TME with a controllable spheroid size. The TME was constructed by printing a blood vessel layer cons ...[more]