Dataset Information

Estimated postnatal p,p'-DDT and p,p'-DDE levels and body mass index at 42?months of age in a longitudinal study of Japanese children.

ABSTRACT:

Background

Children are exposed to p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) through placental and lactational transfer. Some studies have suggested that early-life exposure to these compounds could lead to increased body mass index (BMI) during childhood. Our aim was to assess whether children's exposure during the first 2 years of life is associated with BMI z-score in Japanese children at 42?months of age.

Methods

We used data from a birth cohort (n?=?290) of the Tohoku Study of Child Development. p,p'-DDT and p,p'-DDE levels were measured in breast milk samples collected 1 month after birth, and levels in children were estimated using a toxicokinetic model for three exposure periods (0-6?months, 6-12?months, 12-24?months). Associations between exposure estimates and BMI z-score at 42?months of age were assessed using multivariate linear regression models.

Results

We found no significant association between levels of p,p'-DDT measured in breast milk or estimated in children and BMI z-score. However, we observed associations between estimated p,p'-DDE levels in girls during all postnatal exposure periods and BMI z-score; for each log increase in the estimated p,p'-DDE levels, BMI z-score increased by 0.23 (C.I. 95%: 0.01, 0.45) for the 0-6?months exposure period, 0.26 (C.I. 95%: 0.06, 0.47) for the 6-12?months exposure period, and 0.24 (C.I. 95%: 0.05, 0.43) for the 12-24?months exposure period.

Conclusion

In this study of Japanese children, estimated postnatal p,p'-DDE levels were associated with increased BMI z-score at 42?months of age, mostly in girls. These results are in line with previous studies supporting that early-life exposure to p,p'-DDE may be associated with higher BMI during childhood.

SUBMITTER: Plouffe L

PROVIDER: S-EPMC7216372 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Estimated postnatal p,p'-DDT and p,p'-DDE levels and body mass index at 42 months of age in a longitudinal study of Japanese children.

Plouffe Laurence L Bosson-Rieutort Delphine D Madaniyazi Lina L Iwai-Shimada Miyuki M Nakai Kunihiko K Tatsuta Nozomi N Nakayama Shoji F SF Verner Marc-André MA

Environmental health : a global access science source 20200511 1

<h4>Background</h4>Children are exposed to p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) through placental and lactational transfer. Some studies have suggested that early-life exposure to these compounds could lead to increased body mass index (BMI) during childhood. Our aim was to assess whether children's exposure during the first 2 years of life is associated with BMI z-score in Japanese children at 42 months of age.<h4>Methods</h4>We us ...[more]

PMID: 32393266

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