Metabolome Wide Association Study of serum DDT and DDE in Pregnancy and Early Postpartum.
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ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC7055929 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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Metabolome Wide Association Study of serum DDT and DDE in Pregnancy and Early Postpartum.
Hu Xin X Li Shuzhao S Cirillo Piera P Krigbaum Nickilou N Tran ViLinh V Ishikawa Tomoko T La Merrill Michele A MA Jones Dean P DP Cohn Barbara B
Reproductive toxicology (Elmsford, N.Y.) 20190515
The advancement of high-resolution metabolomics (HRM) and metabolome-wide-association study (MWAS) enables the readout of environmental effects in human specimens. We used HRM to understand DDT-induced alterations of in utero environment and potential health effects. Endogenous metabolites were measured in 397 maternal perinatal serum samples collected during 1959-1967 in the Child Health and Development Studies (CHDS) and in 16 maternal postnatal serum samples of mice treated with or without DD ...[more]
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