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Magnetization transfer and frequency distribution effects in the SSFP ellipse.


ABSTRACT: PURPOSE:To demonstrate that quantitative magnetization transfer (qMT) parameters can be extracted from steady-state free-precession (SSFP) data with no external T1 map or banding artifacts. METHODS:SSFP images with multiple MT weightings were acquired and qMT parameters fitted with a two-stage elliptical signal model. RESULTS:Monte Carlo simulations and data from a 3T scanner indicated that most qMT parameters could be recovered with reasonable accuracy. Systematic deviations from theory were observed in white matter, consistent with previous literature on frequency distribution effects. CONCLUSIONS:qMT parameters can be extracted from SSFP data alone, in a manner robust to banding artifacts, despite several confounds.

SUBMITTER: Wood TC 

PROVIDER: S-EPMC7216875 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Magnetization transfer and frequency distribution effects in the SSFP ellipse.

Wood Tobias C TC   Teixeira Rui P A G RPAG   Malik Shaihan J SJ  

Magnetic resonance in medicine 20191224 2


<h4>Purpose</h4>To demonstrate that quantitative magnetization transfer (qMT) parameters can be extracted from steady-state free-precession (SSFP) data with no external T<sub>1</sub> map or banding artifacts.<h4>Methods</h4>SSFP images with multiple MT weightings were acquired and qMT parameters fitted with a two-stage elliptical signal model.<h4>Results</h4>Monte Carlo simulations and data from a 3T scanner indicated that most qMT parameters could be recovered with reasonable accuracy. Systemat  ...[more]

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