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Improved Acid Resistance of a Metal-Organic Cage Enables Cargo Release and Exchange between Hosts.

ABSTRACT: The use of di(2-pyridyl)ketone in subcomponent self-assembly is introduced. When combined with a flexible triamine and zinc bis(trifluoromethanesulfonyl)imide, this ketone formed a new Zn4 L4 tetrahedron 1 bearing twelve uncoordinated pyridyl units around its metal-ion vertices. The acid stability of 1 was found to be greater than that of the analogous tetrahedron 2 built from 2-formylpyridine. Intriguingly, the peripheral presence of additional pyridine rings in 1 resulted in distinct guest binding behavior from that of 2, affecting guest scope as well as binding affinities. The different stabilities and guest affinities of capsules 1 and 2 enabled the design of systems whereby different cargoes could be moved between cages using acid and base as chemical stimuli.

SUBMITTER: Xu L

PROVIDER: S-EPMC7217015 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Improved Acid Resistance of a Metal-Organic Cage Enables Cargo Release and Exchange between Hosts.

Xu Lin L Zhang Dawei D Ronson Tanya K TK Nitschke Jonathan R JR

Angewandte Chemie (International ed. in English) 20200318 19

The use of di(2-pyridyl)ketone in subcomponent self-assembly is introduced. When combined with a flexible triamine and zinc bis(trifluoromethanesulfonyl)imide, this ketone formed a new Zn<sub>4</sub> L<sub>4</sub> tetrahedron 1 bearing twelve uncoordinated pyridyl units around its metal-ion vertices. The acid stability of 1 was found to be greater than that of the analogous tetrahedron 2 built from 2-formylpyridine. Intriguingly, the peripheral presence of additional pyridine rings in 1 resulted ...[more]

PMID: 32073709

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