Ontology highlight
ABSTRACT:
SUBMITTER: Ling JJ
PROVIDER: S-EPMC7217020 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Ling Jun-Jie JJ Fan Chuyao C Qin Hong H Wang Min M Chen Ji J Wittung-Stafshede Pernilla P Zhu Ting F TF
Angewandte Chemie (International ed. in English) 20200121 9
After realizing mirror-image genetic replication, transcription, and reverse transcription, the biggest challenge in establishing a mirror-image version of the central dogma is to build a mirror-image ribosome-based translation machine. Here, we chemically synthesized the natural and mirror-image versions of three ribosomal proteins (L5, L18, and L25) in the large subunit of the Escherichia coli ribosome with post-translational modifications. We show that the synthetic mirror-image proteins can ...[more]