Mirror image phosphoinositides regulate autophagy.
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ABSTRACT: Autophagosome formation is stimulated by canonical VPS34-dependent formation of phosphatidylinositol 3-phosphate [PI(3)P], which recruits effectors such as WIPI2. However, non-canonical VPS34-independent autophagy has also been proposed. We recently described that PI(5)P regulates autophagosome biogenesis, recruits WIPI2, and rescues autophagy in VPS34-inactivated cells. These alternative autophagy-initiating pathways reveal new druggable targets for treating neurodegeneration and cancer.
SUBMITTER: Vicinanza M
PROVIDER: S-EPMC4905334 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
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