Water-fat separation in spiral magnetic resonance fingerprinting for high temporal resolution tissue relaxation time quantification in muscle.

ABSTRACT:

Purpose

To minimize the known biases introduced by fat in rapid T₁ and T₂ quantification in muscle using a single-run magnetic resonance fingerprinting (MRF) water-fat separation sequence.

Methods

The single-run MRF acquisition uses an alternating in-phase/out-of-phase TE pattern to achieve water-fat separation based on a 2-point DIXON method. Conjugate phase reconstruction and fat deblurring were applied to correct for B₀ inhomogeneities and chemical shift blurring. Water and fat signals were matched to the on-resonance MRF dictionary. The method was first tested in a multicompartment phantom. To test whether the approach is capable of measuring small in vivo dynamic changes in relaxation times, experiments were run in 9 healthy volunteers;

SUBMITTER: Koolstra K 

PROVIDER: S-EPMC7217066 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature