Ontology highlight
ABSTRACT:
SUBMITTER: Zheng N
PROVIDER: S-EPMC7217704 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20191213 24
Insulin has been a life-saving drug for millions of people with diabetes. However, several challenges exist which limit therapeutic benefits and reduce patient convenience. One key challenge is the fibrillation propensity, which necessitates refrigeration for storage. To address this limitation, we chemically synthesized and evaluated a methylene thioacetal human insulin analogue (SCS-Ins). The synthesized SCS-Ins showed enhanced serum stability and aggregation resistance while retaining bioacti ...[more]