Shared distal regulatory regions may contribute to the coordinated expression of human ribosomal protein genes.

ABSTRACT: To identify the potential distal regulatory regions of human ribosomal protein genes (RPGs) and to understand their characteristics, we studied the chromatin interactions in seven cell lines and four primary cell types. We identified 22,797 putative regulatory regions that directly or indirectly interact with human RPG promoters. A large proportion of these regions are only present in one cell line or one cell type, implying that RPGs may be differentially regulated across experimental conditions. We also noticed that groups of RPGs, which are the same groups across cell lines and cell types, share common regulatory regions. These shared regulatory regions by RPGs may contribute to their coordinated regulation. By studying the overrepresented motifs in the identified regulatory regions, we

SUBMITTER: Wang S 

PROVIDER: S-EPMC7217726 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature