Ontology highlight
ABSTRACT:
SUBMITTER: Itskovich SS
PROVIDER: S-EPMC7217953 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200512 1
Despite growing awareness of the biologic features underlying MLL-rearranged leukemia, targeted therapies for this leukemia have remained elusive and clinical outcomes remain dismal. MBNL1, a protein involved in alternative splicing, is consistently overexpressed in MLL-rearranged leukemias. We found that MBNL1 loss significantly impairs propagation of murine and human MLL-rearranged leukemia in vitro and in vivo. Through transcriptomic profiling of our experimental systems, we show that in leuk ...[more]