Ontology highlight
ABSTRACT:
SUBMITTER: Kuriya K
PROVIDER: S-EPMC7218152 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Biochemistry and biophysics reports 20200511
Mononuclear osteoclast precursor cells fuse with each other to become mature multinucleated osteoclasts, which is regulated by dendritic cell-specific transmembrane protein (DC-STAMP). We evaluated the effects of tea extract and catechins on cell-cell fusion and DC-STAMP expression to elucidate their relationship with osteoclast development. When tea extract or epigallocatechin gallate (EGCg) was applied to RAW264.7 cells, multinucleated cells were increased significantly, while tartrate-resista ...[more]